Recent News

What we've been up to

in the

Shankland Lab!

 

 


Watch our video and learn about the unique and rigorous
Nephrology Fellowship Program at the University of Washington



 Highlight on Papers 

More details available on our Research page

Detection of renin lineage cell transdifferentiation to podocytes in the kidney glomerulus with dual lineage tracing

PMID: 29580637

Eng DG, Kaverina NV, Schneider RRS, Freedman BS, Gross KW, Miner JH, Pippin JW, Shankland SJ

Lineage Tracing Aged Mouse Kidneys Shows Lower Number of Cells of Renin Lineage and Reduced Responsiveness to RAAS Inhibition

PMID: 29412700

Hamatani H, Eng DG, Kaverina NV, Gross KW, Freedman, BS, Pippin JW, Shankland SJ

Charting the transcriptional landscape of cells of renin lineage following podocyte depletion

PMID: 29232382

McClelland AD, Lichtnekert J, Eng DG, Pippin JW, Gross KW, Gharib SA, Shankland SJ

WT1 Is Necessary for the Proliferation and Migration of Cells of Renin Lineage Following Kidney Podocyte Depletion

PMID: 28966119

Kaverina NV, Eng DG, Largent AD, Daehn I, Chang A, Gross KW, Pippin JW, Hohenstein P, Shankland SJ

Gene-Edited Human Kidney Organoids Reveal Mechanisms of Disease in Podocyte Development

PMID: 28905451

Kim YK, Refaeli I, Brooks CR, Jing P, Gulieva RE, Hughes MR, Cruz NM, Liu Y, Churchill AJ, Wang Y, Fu H, Pippin JW, Lin LY,  Shankland S,

Vogl AW, McNagny KM, Freedman, BS


ASN 2017- Kidney Week in New Orleans


G.Liu_crop2.jpg

    

Congratulations to Gary
on passing his general examination

Gary is a PhD candidate!


Andrea discussing her research

20th Annual Undergraduate Research Symposium

 


Shankland Lab Research featured on cover of Kidney International

  Shankland Lab Research featured on cover of  Kidney International

Dr. Mariya Sweetwyne's paper accepted to Kidney International

Mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age

PMID: 28063595


New Funding for FSGS Research

FY 2015 Investigator-Initiated Research Award – Partnering PI Option

Suzie Pun – University of Washington

Stuart Shankland – University of Washington


Grants

 

NIH/NIA  (Shankland) 08/15/2016-03/31/2021

Reduced Glomerular Progenitors Impair Regeneration in Aged Kidney

The grant will define how the decline in podocyte number with advancing age cannot adequately be replaced by their neighboring parietal

epithelial cell progenitors, which leads to kidney scarring.

 

DOD  PR151175    (Shankland and Pun)   09/30/2016-04/30/2019         

New podocyte-targeted treatments for focal segmental glomerulosclerosis (FSGS)


We propose the development of two synergistic kidney-targeting technologies: (i) “passive” targeting, kidney-accumulating polymers and (ii)

“active” targeting podocyte-specific peptide

 

DOD  PR151965   (Shankland and Pun)   6/15/2016-12/14/2018

Development of Cell Therapies for FSGS

The major goal of this proposal is to develop urine-derived renal progenitor cells as a cell therapy for treatment of FSGS

 

NIH/NIDDK  1 UH2 DK107343-01   (Shankland and Zheng)   07/01/2015-06/30/2020  

Rebuilding the glomerular filtration barrier by regenerating adult podocytes

 (Re)BuildingAKidney.org

Podocytes are cells in the kidney’s glomerular filtering units that limit the passage of proteins from the blood in to the urine. As adults, they

cannot proliferate to replace , and therefore they are reliant on other stem cells for their regeneration. In this grant, we will study such stem

cells in podocyte repair to rebuild a kidney.

 

NIH/NIDDK 1 R01 DK097598-01A1 (Shankland) PI   07/01/2014-06/30/2019                                                                            

Juxta-glomerular cells serve as glomerular epithelial cell progenitors in glomerular disease

The purpose of this proposal is to study the existing problem of age-related podocyte depletion in a completely new context. The goal is to

prove that with advancing age, kidney regeneration, and thus repair, is inadequate because progenitors are unable to replace and restore

glomerular podocytes. We anticipate that the results will provide compelling evidence for a new paradigm in aging kidneys in which recently

identified progenitors are unable to adequately regenerate to replace podocytes, which leads to glomerulosclerosis and reduced kidney

function.

 

NIH/NIDDK   5 T32 DL07467-31 (Shankland)  7/15/1993-6/30/2019

 Training in Renal Disease

This is a training grant that supports research training for three M.D. post-graduate fellows who undergoperiods of both renal and basic

science research training.

 

NIH R01 5 R01 DK093493-02 (Shankland) PI   9/03/2012-6/30/2017                                                                                    

Pericyte-endothelial cross talk in vascular stability after kidney injury

These studies will investigate the mechanisms by which pericytes nurture kidney blood vessels and the mechanisms by which they detach in

response to injury and thereafter fail to nurture. In understanding  these processes we hope to develop new therapies to treat kidney diseases.

 


Select Presentations

  • Society of Toxicologic Pathology Annual Meeting - 2018
  • International Podocyte Conference - 2018
  • American Society of Nephrology Annual Meeting, New Orleans, LA - 2017

“Podocyte Regeneration from Renin Lineage Cells”

  •  American Society of Nephrology Annual Meeting, San Diego, CA - 2015

"What is Aging Nephropathy?" 

"Role of Parietal Cells Following Glomerular Injury"

  • New York Renal Society - 2015
  • German Society of Nephrology - 2014
  • International Podocyte Conference - 2014
  • National Kidney Foundation Annual Meeting - 2014
  • SSCI Annual Meeting - 2014
Shankland-at-podium.jpg

12th International Podocyte Conference

Posters

Kaverina, Natalya

Multi-Clonal Population of Cells of Renin Lineage (CoRL) Transdifferentiate into Podocytes and PECs in Experimental FSGS

 

Lichtnekert, Julia

RAS Inhibition Enhances Proliferation and Migration of Cells of Renin Lineage (CoRL) as Progenitors in Experimental FSGS



The Lab Gang


Shankland Lab