NIH 1R01 AG046231-01A1 (Shankland) 06/15/2016-12/14/2021
Reduced Glomerular Progenitors Impair Regeneration in Aged Kidney
The grant will define how the decline in podocyte number with advancing age cannot adequately be replaced by their neighboring parietal
epithelial cell progenitors, which leads to kidney scarring.
DOD PR151175 (Shankland) 09/30/2016-09/29/2019
New podocyte-targeted treatments for focal segmental glomerulosclerosis (FSGS)
Our overall goals are to improve drug biodistribution directly to podocytes while decreasing systemicexposure to active drug, and to
demonstrate drug efficacy and safety in an animal model of FSGS. To meet these objectives we propose the following aims: Aim 1. Optimize
and characterize cyclic “sunflower” polymer kidney accumulation in a mouse model of FSGS. The goal of this aim is to synthesize and
optimize a drug delivery vehicle that preferentially distributes to and is retained in the kidney after injection.
NIH/NIDDK 5 T32 DL07467-31 (Shankland) 7/15/2014-6/30/2024
Training in Renal Disease
This is a training grant that supports research training for three M.D. post-graduate fellows who undergoperiods of both renal and basic
science research training.
NIH/NIDDK 1 R01 DK097598-01A1 (Shankland) 08/05/2014-06/30/2020
Juxta-glamerular cells serve as glomerular epithelial cell progenitors in glomerular disease
The purpose of this proposal is to study the existing problem of age-related podocyte depletion in a completely new context. The goal is to
prove that with advancing age, kidney regeneration, and thus repair, is inadequate because progenitors are unable to replace and restore
glomerular podocytes. We anticipate that the results will provide compelling evidence for a new paradigm in aging kidneys in which
recently identified progenitors are unable to adequately regenerate to replace podocytes, which leads to glomerulosclerosis and reduced
NIH/NIDDK 1 UH2 DK107343-01 (Shankland and Zheng) 09/23/2015-08/31/2020
Rebuilding the glomerular filtration barrier by regenerating adult podocytes (Re)BuildingAKidney.org
Podocytes are cells in the kidney’s glomerular filtering units that limit the passage of proteins from the blood in to the urine. As adults, they
cannot proliferate to replace themselves, and therefore they are reliant on other stem cells for their regeneration. In this grant, we will study
such stem cells in podocyte repair to rebuild a kidney.
NIH/NIDDK U2CDK114886 Central Hub for Kidney Precision Medicine 09/15/17-06/30/22
MPI: Himmelfarb, Iyengar, Kretzler
The overarching objective of the KPMP Central Hub is to facilitate logistics and operations required to promote scientific rigor,
patient safety, and the successful interdisciplinary team science to for major advances in kidney precision medicine.