Current Funding

 

NIH  1R01 AG046231-01A1    (Shankland)   06/15/2016-12/14/2021           

Reduced Glomerular Progenitors Impair Regeneration in Aged Kidney


The grant will define how the decline in podocyte number with advancing age cannot adequately be replaced by their neighboring parietal

epithelial cell progenitors, which leads to kidney scarring.

 

DOD  PR151175    (Shankland)   09/30/2016-09/29/2019        

New podocyte-targeted treatments for focal segmental glomerulosclerosis (FSGS)


Our overall goals are to improve drug biodistribution directly to podocytes while decreasing systemicexposure to active drug, and to

demonstrate drug efficacy and safety in an animal model of FSGS. To meet these objectives we propose the following aims: Aim 1. Optimize

and characterize cyclic “sunflower” polymer kidney accumulation in a mouse model of FSGS. The goal of this aim is to synthesize and

optimize a drug delivery vehicle that preferentially distributes to and is retained in the kidney after injection.

NIH/NIDDK   5 T32 DL07467-31 (Shankland)  7/15/2014-6/30/2024

 Training in Renal Disease

This is a training grant that supports research training for three M.D. post-graduate fellows who undergoperiods of both renal and basic

science research training.

 

NIH/NIDDK 1 R01 DK097598-01A1 (Shankland)  08/05/2014-06/30/2020                                                                            

Juxta-glamerular cells serve as glomerular epithelial cell progenitors in glomerular disease

The purpose of this proposal is to study the existing problem of age-related podocyte depletion in a completely new context. The goal is to

prove that with advancing age, kidney regeneration, and thus repair, is inadequate because progenitors are unable to replace and restore

glomerular podocytes. We anticipate that the results will provide compelling evidence for a new paradigm in aging kidneys in which

recently identified progenitors are unable to adequately regenerate to replace podocytes, which leads to glomerulosclerosis and reduced

kidney function.

 

NIH/NIDDK  1 UH2 DK107343-01 (Shankland and Zheng)   09/23/2015-08/31/2020  

Rebuilding the glomerular filtration barrier by regenerating adult podocytes  (Re)BuildingAKidney.org

Podocytes are cells in the kidney’s glomerular filtering units that limit the passage of proteins from the blood in to the urine. As adults, they

cannot proliferate to replace themselves, and therefore they are reliant on other stem cells for their regeneration. In this grant, we will study

such stem cells in podocyte repair to rebuild a kidney. 

 

NIH/NIDDK U2CDK114886 Central Hub for Kidney Precision Medicine 09/15/17-06/30/22

MPI: Himmelfarb, Iyengar, Kretzler

Co-I: Shankland

The overarching objective of the KPMP Central Hub is to facilitate logistics and operations required to promote scientific rigor,

patient safety, and the successful interdisciplinary team science to for major advances in kidney precision medicine.

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